What Doesn't Work to Treat Depression: Tricyclics

Furthermore, research suggests that tricyclics, another type of antidepressant, appear to be ineffective for treating depression. For instance, the effectiveness of tricyclics was considered in a review of all double-blind, placebo-controlled efficacy trials of tricyclic antidepressants with depressed youth published between 1985 and 1994 (Sommers-Flanagan & Sommers-Flanagan, 1996). The researchers conclude that tricyclics are no more effective than a placebo even in studies designed to maximize the effects of the antidepressants. The authors note, very importantly, that the lack of evidence could be a byproduct of poorly conducted evaluations. Also, the sample of studies that the authors chose was very small (i.e., five). However, a more recent, rigorous review of experimental research on the effectiveness of tricyclics on adolescent depression continued to show that they do not work (Hazell, O'Connell, Heathcote, & Henry, 1999).


 
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